Not just physical damage, I had a really good mechanic in rural Georgia. Found him on recommendation from some high end people two counties away. He knew I worked for a company making commercial Ice machines. He asked about what refrigerants we were using. As we talked about the direction the regulations were heading, he confessed he couldn’t afford to keep up with upgrades to his AC equipment.
I noticed my son’s new bar refrigerator ran on Pentane. New regulations, much higher cost!!